The answer to this question would depend on factors that aren't given. How did you meet the prospect, why are they even talking or communicating with you, where did you meet them, what have you talked about with them, how well do you know your prospect?
You need to develop both your initial contact skills, and your follow-up skills. You need to know which you are doing, and act accordingly. Both are important, and one without the other is useless.
